Ymele:Protease mechanisms.png
Micelness þisre forebysene: 800 be 307 dotta. Oðra metinga brædo: 320 be 123 dotta | 640 be 245 dotta | 1,437 be 551 dotta.
Frumlicu ymele (1,437 × 551 pixela, ymelan micelness: 67 KB, MIME cynn: image/png)
Scortness
| Towritenness |
English: Differences in cysteine and serine proteolysis mechanisms.
The protease (black) performs a nucleophilic attack on peptide substrate (red) to form a tetrahedral intermediate. This breaks down by ejection of the first product, the substrate C-terminus, to form the acyl-enzyme intermediate. Water replaces the first product and hydrolysis occurs via a second tetrahedral intermediate to regenerate free enzyme. Indicated differences are (a) the deprotonated cysteine, (b) aspartate (grey) not present in all cysteine proteases, (c) concerted deprotonation of serine, (d) aspartate hydrogen bonding, (e) amide protonation of the first leaving group, (f) alcohol protonation of the serine leaving group. |
| Tælmearc | |
| Fruma | Thomas, Shafee, (2014). "Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity". PhD Thesis. University of Cambridge. |
| Dædfruma | Thomas Shafee |
Leaf:
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution 4.0 International license.
- Þu most:
- bryttian – to copy, distribute and transmit the work
- to remix – andwendan þæt weorc
- Under the following conditions:
- hlígung – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Ymelan stær
Swing dæg/tide mid mys to seonne þa ymelan swa heo wæs on þære tide geywed.
| Dæg/Tid | Metungincel | Micelnesse gemetu | Brucend | Ymbspræc | |
|---|---|---|---|---|---|
| nu | 20:56, 11 Winterfylleð 2013 | | 1,437 × 551 (67 KB) | Evolution and evolvability | User created page with UploadWizard |
Biliþbendas
Þǣr sind nāne trametas þe bindaþ tō þissum biliðe.
Ymelan eormen nytt
Þas wiki brucaþ þissa ymelena:
- Nytt on es.wikipedia.org
- Nytt on zh.wikipedia.org
